{"id":352,"date":"2024-09-26T12:05:19","date_gmt":"2024-09-26T12:05:19","guid":{"rendered":"https:\/\/saatall.com\/?p=352"},"modified":"2025-07-09T12:54:15","modified_gmt":"2025-07-09T12:54:15","slug":"vitiligo","status":"publish","type":"post","link":"https:\/\/drfatmaerden.com\/vitiligo\/","title":{"rendered":"Vitiligo"},"content":{"rendered":"

Vitiligo ve Pigmentasyon Hastal\u0131klar\u0131<\/strong><\/h4>\n
Vitiligo ve pigmentasyon hastal\u0131klar\u0131, deri renginin daha a\u00e7\u0131k veya daha koyu renkte yamalar \u015feklinde tutabilen ve genellikle kozmetik a\u00e7\u0131dan rahats\u0131zl\u0131k veren hastal\u0131klard\u0131r.<\/div>\n

Deri rengi;<\/strong><\/h4>\n
D\u0131\u015far\u0131dan besinlerle ald\u0131\u011f\u0131m\u0131z karotenoidler (sar\u0131 renk),<\/div>\n
Endojen yani v\u00fccudumuzda melanositler taraf\u0131ndan \u00fcretilen melanin (kahverengi renk)<\/div>\n
Damar yap\u0131lar\u0131 i\u00e7indeki hemoglobin yap\u0131lar\u0131<\/div>\n

Derinin kal\u0131nl\u0131\u011f\u0131<\/strong><\/h4>\n
Derinin \u0131\u015f\u0131\u011f\u0131 k\u0131rma ve emme \u00f6zelli\u011fi taraf\u0131ndan olu\u015fturulur.<\/div>\n
Fakat, melanin deri rengini belirleyen ana bile\u015fendir. Melanosit h\u00fccreleri taraf\u0131ndan \u00fcretilen melanin maddesi keratinosit denen deri h\u00fccrelerine aktar\u0131m\u0131 yap\u0131l\u0131r.<\/div>\n
Asl\u0131nda Melanin, ultraviyoleyi (UV) emerek g\u00fcne\u015f \u0131\u015f\u0131\u011f\u0131n\u0131n zararl\u0131 etkilerinden koruyan bir \u015femsiye g\u00f6revi g\u00f6r\u00fcr. A\u00e7\u0131k renkli bireylerde daha az, koyu tenlilerde daha fazla bulunurlar.<\/div>\n
Pigmentasyon hastal\u0131klar\u0131n\u0131 a\u015fa\u011f\u0131da belirtilen \u015fekilde incelemek konunun daha anla\u015f\u0131l\u0131r olmas\u0131n\u0131 sa\u011flayacakt\u0131r:<\/div>\n
Hipopigmentasyon veya depigmentasyon; Melanosit kayb\u0131, Melanositlerin melanin \u00fcretmesinin etkilenmesi, melanozomlar\u0131n transferinde bozukluk ile ortaya \u00e7\u0131kan deri renginin a\u00e7\u0131lmas\u0131yla seyreden bozukluklard\u0131r.<\/div>\n

Bunlar;<\/h4>\n
\u2022 Postinflamatuar hipopigmentasyon<\/div>\n
\u2022 Albinizm<\/div>\n
\u2022 Vitiligo<\/div>\n
\u2022 \u0130diopatik guttat hipomelanozis<\/div>\n
\u2022 Piebaldizm<\/div>\n
\u2022 Mesleki maruziyetler<\/div>\n
Bu tablolardan en s\u0131k Vitiligo ile kar\u015f\u0131la\u015f\u0131lmaktad\u0131r.<\/div>\n
Hiperpigmentasyon: Dermal veya epidermal deri tabakalar\u0131ndaki Melanosit say\u0131s\u0131 ve aktivitesinde art\u0131\u015f dolay\u0131s\u0131yla, deri renginin koyula\u015fmas\u0131 ile giden bozukluklard\u0131r. Bunlar;<\/div>\n
\u2022Postinflamatuar hiperpigmentasyon<\/div>\n
\u2022 Hemakromatozis<\/div>\n
\u2022 Melazma<\/div>\n
\u2022 Mesleki temas: G\u00fcm\u00fc\u015f, arsenik, kur\u015fun maruziyeti<\/div>\n
Bu grupta, melazma ve postinflamatuar hiperpigmentasyon olduk\u00e7a s\u0131k g\u00f6r\u00fclmekle birlikte leke konu ba\u015fl\u0131\u011f\u0131 alt\u0131nda de\u011ferlendirilecektir.<\/div>\n

V\u0130T\u0130L\u0130GO<\/strong><\/h4>\n
Vitiligo, Melanin dedi\u011fimiz maddeyi \u00fcreten h\u00fccreler olan melanosit y\u0131k\u0131m\u0131 ile seyreden, kesin sebebi bilinmeyen bir renk kayb\u0131 hastal\u0131\u011f\u0131d\u0131r.<\/div>\n

Vitiligo Hastal\u0131\u011f\u0131n\u0131n Nedenleri nelerdir?<\/strong><\/h4>\n
\u00c7e\u015fitli nedenlerle maruziyetlerden, enfeksiyonlara kadar olu\u015fan baz\u0131 maddeler veya antikorlar\u0131n melanositleri par\u00e7alamas\u0131 veya y\u0131kmas\u0131na ba\u011fl\u0131 ortaya \u00e7\u0131kar.<\/div>\n
Vitiligo bazen tiroid hastal\u0131klar\u0131na veya otoantikorx varl\u0131\u011f\u0131na e\u015flik eder; bu sebeple de baz\u0131 hastalarda birtak\u0131m kan testleri gerekebilir. Vitiligo bula\u015f\u0131c\u0131 de\u011fildir.<\/div>\n
Deride pigment kayb\u0131ndan kaynaklanan beyaz alanlar\u0131n g\u00f6r\u00fcld\u00fc\u011f\u00fc bu hastal\u0131k; en s\u0131k y\u00fcz, dudak, el, kol, bacak ve genital alanlar olmak \u00fczere v\u00fccudun herhangi bir k\u0131sm\u0131n\u0131 etkileyebilir. G\u00f6z, dudak gibi k\u0131s\u0131mlar\u0131n \u00e7evresini, k\u0131vr\u0131m b\u00f6lgelerini ve travmaya a\u00e7\u0131k alanlar\u0131 etkiledi\u011fini \u00e7\u0131karabiliriz.<\/div>\n
D\u00fcnya n\u00fcfusunun %1\u2019nde g\u00f6r\u00fcl\u00fcr ve erkek, kad\u0131n ve t\u00fcm \u0131rklar\u0131 e\u015fit oranda etkiler. 20 ya\u015f\u0131n alt\u0131nda ba\u015flama s\u0131kl\u0131\u011f\u0131 yakla\u015f\u0131k ~%50\u2018dir. Aile \u00f6yk\u00fcs\u00fc varl\u0131\u011f\u0131nda g\u00f6r\u00fclme olas\u0131l\u0131\u011f\u0131 %10 kadard\u0131r.<\/div>\n
Hastal\u0131k seyri ve \u015fiddeti ki\u015fiye g\u00f6re de\u011fi\u015fir; genellikle yava\u015f ilerler, baz\u0131 hastalarda sabit kal\u0131rken baz\u0131 hastalarda ilerleme veya gerileme g\u00f6sterebilir. Baz\u0131 hastalarda bir miktar renk geri gelir, nadiren de tamamen kendili\u011finden d\u00fczelir.<\/div>\n

Vitiligo Tutulum Alanlar\u0131na G\u00f6re Alt Tiplere Ayr\u0131l\u0131r:<\/h4>\n
    \n
  • Lokalize veya fokal<\/li>\n
  • Segmental<\/li>\n
  • Universal<\/li>\n
  • Akrofasiyal<\/li>\n<\/ul>\n
    Generalize: En s\u0131k g\u00f6zlenen tiptir: y\u00fcz, g\u00f6z, a\u011f\u0131z ve burun \u00e7evresi, el s\u0131rtlar\u0131, aksilla, meme ba\u015flar\u0131, penis, vulva, diz ve dirseklerde g\u00f6zlenir.<\/div>\n
    Trikrom vitiligo \u00fc\u00e7 renkli g\u00f6r\u00fcnt\u00fc verir. (Depigmente mak\u00fcl \u00e7evresinde hiperpigmente halka)<\/div>\n
    Tutulum alanlar\u0131ndaki k\u0131llarda beyazlama vard\u0131r.<\/div>\n

    Koebner Pozitifli\u011fi Durumu<\/h4>\n
    Baz\u0131 dermatolojik hastal\u0131klarda fiziksel travmalardan birka\u00e7 hafta sonra ortaya \u00e7\u0131kan hastal\u0131\u011f\u0131n kendisine benzer d\u00f6k\u00fcnt\u00fcler demektir. Vitiligo hastal\u0131\u011f\u0131nda da pozitiflik olabilir, travmaya maruz kalan alanlarda (g\u00fcne\u015f yan\u0131\u011f\u0131, ka\u015f\u0131ma gibi travmalarla) vitiligo lezyonu meydana gelebilir.<\/div>\n
    Tan\u0131, dermatoloji hekimleri taraf\u0131ndan kolayca konur. Ek olarak tan\u0131y\u0131 desteklemek i\u00e7in wood \u0131\u015f\u0131\u011f\u0131 incelemesi ve nadiren de deri biyopsisi gerekmektedir.<\/div>\n
    Asl\u0131nda bir\u00e7ok dermatolojik hastal\u0131kta deri renginden daha a\u00e7\u0131k renkte olabilir ve vitiligo ile kar\u0131\u015ft\u0131r\u0131labilir. En s\u0131k ay\u0131r\u0131c\u0131 tan\u0131da d\u00fc\u015f\u00fcnd\u00fc\u011f\u00fcm\u00fcz hastal\u0131klar:<\/div>\n
      \n
    • Albinizm<\/li>\n
    • Piebaldizm<\/li>\n
    • \u0130diyopatik guttat hipomelanozis<\/li>\n
    • Pitriyazis alba<\/li>\n
    • Tinea Versikolor alba<\/li>\n
    • Lepra<\/li>\n
    • Sifiliz ikinci devir l\u00f6kodermas\u0131<\/li>\n<\/ul>\n
      Vitiligo tedavisinde zorland\u0131\u011f\u0131m\u0131z dermatolojik hastal\u0131klardan biridir. Tedavi i\u00e7in; hastan\u0131n ya\u015f\u0131, e\u015flik hastal\u0131klar\u0131, hastal\u0131\u011f\u0131n \u015fiddeti, tutulum alanlar\u0131 ve tabi ki tedavi uyumunu etkileyecek sosyoekonomik durumu da \u00f6nemlidir.<\/div>\n
      Tedavide ama\u00e7lar\u0131m\u0131z\u0131 \u00fc\u00e7 ba\u015fl\u0131k \u015feklinde s\u0131n\u0131fland\u0131rabiliriz:<\/div>\n
      \u2022 Repigmentasyon: Tekrar deri rengini kazanmas\u0131.<\/div>\n
      \u2022 Kozmetik kamuflaj: \u00d6zellikle tedavi istemeyen veya tedaviye diren\u00e7li hastalarda \u00f6nerilen tedavidir. Mikroblading veya d\u00f6vme ile kamuflaj sa\u011flanabilir.<\/div>\n
      \u2022 Depigmentasyon: \u00c7ok y\u00fcksek alan\u0131n a\u00e7\u0131ld\u0131\u011f\u0131 hastalarda ama\u00e7 repigmentasyon de\u011fil depigmentasyondur. Yani kalan normal deri alanlar\u0131n\u0131n deri rengini a\u00e7arak e\u015fitlemektir. Tabi hastan\u0131n da onay\u0131 varsa.<\/div>\n
      G\u00fcne\u015f koruyucu:\u00a0Koruyucu \u015femsiyemiz olan melanin kayb\u0131 oldu\u011fu i\u00e7in mutlaka hem g\u00fcne\u015f koruyucu krem kullan\u0131m\u0131na dikkat edilmeli, hem de g\u00fcne\u015ften korunma davran\u0131\u015f\u0131na hayat\u0131n\u0131 \u015fekillendirmelidir.<\/div>\n
      Topikal Steroid ve Topikal Takrolimus-Pimekrolimus:\u00a0Uzun s\u00fcreli olarak \u00e7ok dikkatli bir \u015fekilde d\u00f6n\u00fc\u015f\u00fcml\u00fc kulland\u0131\u011f\u0131m\u0131z molek\u00fcller. Hekim kontrol\u00fcnde uzun s\u00fcre kullan\u0131m\u0131 s\u0131k\u0131nt\u0131 yaratmayacakt\u0131r. Topikal takrolimus\/pimekrolimus kullan\u0131m\u0131 ba\u015flang\u0131c\u0131nda hafif irritasyon dedi\u011fimiz k\u0131zar\u0131kl\u0131k, ka\u015f\u0131nt\u0131 yanma olabilir. S\u0131k ve yeterli nemlendirici kullan\u0131m\u0131 ve tedaviye al\u0131\u015fana kadar kortizonlu kremlerle birlikte kullan\u0131lmas\u0131 bu s\u0131k\u0131nt\u0131lar\u0131 azaltacakt\u0131r.<\/div>\n
      Fototerapiler (PUVA, UVB, Dar-band UVB, lokal): En s\u0131k dar bant UVB, lokal tutulumlarda mikro puva kullan\u0131labilmektedir. Yan\u0131t\u0131 de\u011ferlendirmek i\u00e7in biraz zaman gereklidir. Sosyal uyum gerektirir.<\/div>\n

      Excimer Lazer<\/strong><\/h4>\n
      Fraksiyonel Karbondioksit lazer uygulamas\u0131 ve Plateletten Zengin Plazma kombinasyonu<\/div>\n
      Melanosit Otogreftleme (Sa\u00e7l\u0131 deriden mikrogreft al\u0131p tutulan alana enjeksiyonu) gibi tedaviler uygulanabilmektedir.<\/div>\n
      Melanositlerin y\u0131k\u0131m\u0131n\u0131 azaltmaya y\u00f6nelik bitkisel takviyeler (Polypodium leucotomos, alfa-lipoik asit gibi) kullan\u0131labilir.<\/div>\n","protected":false},"excerpt":{"rendered":"

      Vitiligo ve Pigmentasyon Hastal\u0131klar\u0131 Vitiligo ve pigmentasyon hastal\u0131klar\u0131, deri renginin daha a\u00e7\u0131k veya daha koyu renkte yamalar \u015feklinde tutabilen ve genellikle kozmetik a\u00e7\u0131dan rahats\u0131zl\u0131k veren hastal\u0131klard\u0131r. Deri rengi; D\u0131\u015far\u0131dan besinlerle ald\u0131\u011f\u0131m\u0131z karotenoidler (sar\u0131 renk), Endojen yani v\u00fccudumuzda melanositler taraf\u0131ndan \u00fcretilen melanin (kahverengi renk) Damar yap\u0131lar\u0131 i\u00e7indeki hemoglobin yap\u0131lar\u0131 Derinin kal\u0131nl\u0131\u011f\u0131 Derinin \u0131\u015f\u0131\u011f\u0131 k\u0131rma ve emme […]<\/p>\n","protected":false},"author":1,"featured_media":353,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-352","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dermatolojik-tedaviler"],"yoast_head":"\nVitiligo Hastal\u0131\u011f\u0131 Ankara - Uzm.Dr. Fatma Erden<\/title>\n<meta name=\"description\" content=\"Vitiligo tedavisi ile ciltteki beyaz lekeleri azalt\u0131n. 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