{"id":296,"date":"2024-09-26T11:09:25","date_gmt":"2024-09-26T11:09:25","guid":{"rendered":"https:\/\/saatall.com\/?p=296"},"modified":"2025-07-09T12:15:32","modified_gmt":"2025-07-09T12:15:32","slug":"leke-tedavisi","status":"publish","type":"post","link":"https:\/\/drfatmaerden.com\/leke-tedavisi\/","title":{"rendered":"Leke Tedavisi"},"content":{"rendered":"
LEKE (H\u0130PERP\u0130GMENTASYON) VE DER\u0130<\/strong><\/div>\n
Kar\u015f\u0131l\u0131kl\u0131 ileti\u015fimde en \u00e7ok dikkat etti\u011fimiz b\u00f6lge, y\u00fcz b\u00f6lgesidir. Bu b\u00f6lgede bulunan ve \u00e7o\u011fu bireyin ya\u015fam kalitesini bozan sorunlardan biri olan leke, dermatolojik hastal\u0131klar aras\u0131nda en \u00e7ok zorland\u0131\u011f\u0131m\u0131z deri problemlerinden biridir. \u00d6zellikle kad\u0131nlarda, estetik a\u00e7\u0131dan daha b\u00fcy\u00fck endi\u015feler do\u011furdu\u011funu da ekleyelim.<\/div>\n
DER\u0130 RENG\u0130 FARKLILIKLARI VE F\u0130ZYOLOJ\u0130S\u0130NE DA\u0130R<\/strong><\/div>\n
Derimiz renk a\u00e7\u0131s\u0131ndan farkl\u0131 tiplere sahip ve rengini olu\u015fturan bir\u00e7ok neden aras\u0131nda en \u00f6nemlisi de melanin i\u00e7eri\u011fidir. Her ne kadar (siyah veya beyaz gibi) etnik farkl\u0131l\u0131klar olsa da melanin maddesinin \u00fcretimini yapan h\u00fccreler olan melanosit say\u0131lar\u0131, asl\u0131nda her bireyde ve her \u0131rkta da ayn\u0131d\u0131r.<\/div>\n
PEK\u0130 DER\u0130 T\u0130P\u0130 FARKLILI\u011eI NASIL OLU\u015eUYOR?<\/strong><\/div>\n
Deri tipi farkl\u0131l\u0131\u011f\u0131 temel olarak, melanin denen maddenin miktar\u0131na ve da\u011f\u0131l\u0131m\u0131na ba\u011fl\u0131d\u0131r. Melanin iki farkl\u0131 tipi vard\u0131r: \u00f6melanin(eumelanin) ve feomelanin. Eumelaninin antioksidan yani protektif,koruyucu; feomelanin de prooksidan yani fototoksik hareket etti\u011fi ifade edilmi\u015ftir. Bireylerdeki eumelanin\/feomelanin oran\u0131 bu nedenle \u00f6nemlidir. Koyu tenli bireylerde de eumelanin\/feomelanin oran\u0131 y\u00fcksek oldu\u011fu i\u00e7in, a\u00e7\u0131k tenli bireylerde de bu oran d\u00fc\u015f\u00fck oldu\u011fu i\u00e7in g\u00fcne\u015fe daha fazla duyarl\u0131d\u0131r.<\/div>\n
Melanin maddesi \u00fcretimi, tirozin aminoasidinden, melanosit h\u00fccreleri i\u00e7indeki melanozomlarda ger\u00e7ekle\u015fir ve keratinosit denen h\u00fccrelere aktar\u0131l\u0131r. Irksal ve etnik farkl\u0131l\u0131klar da i\u015fte bu melanozom denen yap\u0131lar\u0131n b\u00fcy\u00fckl\u00fck ve yo\u011funluk fark\u0131na dayal\u0131 ortaya \u00e7\u0131kar.<\/div>\n
Melanin maddesi, leke \u015fikayetinin \u00e7o\u011funlukla nedeni. Melanin maddesi \u00fcretim yoluna da melanogenez yolu diyoruz. Ve biz hekimler bu yolak \u00fczerinde g\u00f6revli yap\u0131lar\u0131 inhibe ederek yani engelleyerek tedavi etmeye \u00e7al\u0131\u015f\u0131yoruz.<\/div>\n
LEKE OLU\u015eUM NEDENLER\u0130?<\/strong><\/div>\n
Leke olu\u015fum nedenleri \u00e7ok \u00e7e\u015fitlidir;<\/div>\n
    \n
  • Yap\u0131sal<\/li>\n
  • Kullan\u0131lan ila\u00e7lar (do\u011fum kontrol haplar\u0131, hormonlu spiral, demir ila\u00e7lar\u0131, romatizmal ila\u00e7lar, kortizon kullan\u0131m\u0131 gibi)<\/li>\n
  • Hormonal de\u011fi\u015fiklikler; gebelik, polikistik over hastal\u0131\u011f\u0131, tiroid bezi bozukluklar\u0131, obezite, ins\u00fclin direnci, cushing gibi hormonal de\u011fi\u015fiklik yapan endokrin bozukluklar<\/li>\n
  • Enfeksiyonlar; u\u00e7uk gibi bu b\u00f6lgede s\u0131k tekrarlayan enfeksiyonlar, k\u0131l bat\u0131klar\u0131<\/li>\n
  • \u0130rritasyon yani tahri\u015fe ba\u011fl\u0131 tablolar;<\/li>\n
  • Di\u015f macunu veya k\u00f6p\u00fc\u011f\u00fcn a\u011f\u0131z \u00e7evresine yo\u011fun temas\u0131<\/li>\n
  • \u00d6zellikle g\u00fcne\u015f ile temas\u0131nda pigmentasyon b\u0131rakacak \u00fcr\u00fcnlerin yanl\u0131\u015f kullan\u0131m\u0131 (silverdin kremi y\u00fcze uygulamak gibi)<\/li>\n
  • A\u011f\u0131z i\u00e7i implant\u0131<\/li>\n
  • G\u0131dalar; turun\u00e7giller, domates vs.<\/li>\n
  • Alerjik hastal\u0131klar:<\/li>\n
  • Alerjik egzama; a\u011fda bantlar\u0131ndaki re\u00e7ineler veya ba\u015fka maddelere ba\u011fl\u0131 alerjik yan\u0131t, atopik dermatit<\/li>\n
  • Nikel alerjisi varl\u0131\u011f\u0131 (kabuklu kuruyemi\u015f, kabuklu deniz \u00fcr\u00fcnleri ve konserve g\u0131dalar) (nikel yo\u011funlu\u011fu nedeniyle)<\/li>\n
  • Sigara kullan\u0131m\u0131: nikotin birikimine ba\u011fl\u0131 olarak<\/li>\n
  • Fiziksel travmalar: \u00f6zellikle epilasyon ama\u00e7l\u0131 uygulanan s\u0131cak a\u011fdaya ba\u011fl\u0131 yan\u0131klar, y\u00fcz usturalama ve lazer epilasyon sonras\u0131 olu\u015fabilir.<\/li>\n<\/ul>\n
    LEKE TEDAV\u0130 P\u0130RAM\u0130D\u0130M\u0130Z<\/strong><\/div>\n
    Leke tedavisinde tedavi piramidinin en taban k\u0131sm\u0131nda; g\u00fcne\u015ften korunma vard\u0131r. Yukar\u0131da da ifade edildi\u011fi gibi, leke olu\u015fum yolu olan melanogenez yolunu; Ultraviole (UV) yani g\u00fcne\u015f maruziyeti, genetik yatk\u0131nl\u0131k, ya\u015f alma ve hormonal fakt\u00f6rler aktive eder. Ve maalesef bu fakt\u00f6rlerden tek de\u011fi\u015ftirebildi\u011fimiz \u015fey, UV maruziyeti.<\/div>\n
    Yani konu yine yaz k\u0131\u015f demeden, do\u011fru ve yeterli g\u00fcne\u015f koruyucu kullan\u0131m\u0131 ve g\u00fcne\u015ften korunma davran\u0131\u015flar\u0131na geliyor. Leke hastalar\u0131nda, UV indexine dikkat etmek, en az SPF 30+ fiziksel \u00f6zellikte g\u00fcne\u015f koruyucu kullanmak \u00f6nerilmektedir. \u0130\u00e7erik olarak titanyum dioksit, demir 3 oksit, \u00e7inko oksit i\u00e7erikli \u00fcr\u00fcnler ve Tinted dedi\u011fimiz fond\u00f6ten tarz\u0131nda \u00fcr\u00fcnler kamuflaj sa\u011flay\u0131c\u0131 oldu\u011fu i\u00e7in tercih edilmelidir.<\/div>\n
    Piramidin 2. basama\u011f\u0131nda; uygulad\u0131\u011f\u0131m\u0131z ya da ev devam tedavisi olarak tavsiye etti\u011fimiz uygun i\u00e7erikte \u00fcr\u00fcnler, kar\u0131\u015f\u0131mlar, kremler var. Bu \u00fcr\u00fcnlerin \u00e7o\u011funda, melanin olu\u015fumunu engellemek ya da var olan melanini yok etmeyi hedefleyen molek\u00fcller vard\u0131r.<\/div>\n
    Bu molek\u00fclleri hadi tan\u0131yal\u0131m;<\/strong><\/div>\n
    Hidrokinon:<\/u> 50 y\u0131l\u0131 a\u015fk\u0131n s\u00fcreden beri kullan\u0131lan alt\u0131n standart \u00fcr\u00fcnlerden. Leke olu\u015fumunun \u00e7o\u011fu basama\u011f\u0131nda etkili (melanozom formasyonu melanizasyonu ve hatta DNA, RNA sentezi \u00fczerinden azalt\u0131r, tirozinaz enzimini inhibe eder)<\/div>\n
    Azelaik asit:<\/u> Melanositlere kar\u015f\u0131 toksik ve antiproliferatiftir. Serbest radikalleri azalt\u0131r, tirozinaz enzimini inhibe eder.<\/div>\n
    Retinoidler (adapalen, tretinoin, tazarotene ve retinoik asit)<\/u>: Tirozinaz enzim inhibisyonu sa\u011flar, melanozom transferi ve melanin sentezini azalt\u0131r.<\/div>\n
    Mequinol Mequinol (4-hydroxyanisole)<\/u>: Hidrokinon derivesidir, tirozinaz enzim inhibisyonu sa\u011flar ve melanin \u00f6nc\u00fc maddelerinin olu\u015fumunu azalt\u0131r.<\/div>\n
    Kojik Asit:<\/u> Tirozinaz enzim aktivat\u00f6r\u00fc bak\u0131r\u0131 ba\u011flayarak enzimin \u00e7al\u0131\u015fmas\u0131n\u0131 inhibe eder.<\/div>\n
    Askorbik Asit (C vitamini):<\/u> Bak\u0131r ile etkile\u015fime girerek tirozinaz enzimini inhibe eder, melanogenezi inhibe eder. Tek ba\u015f\u0131na molek\u00fcler anlamda stabil kalamad\u0131\u011f\u0131 i\u00e7in; meyan k\u00f6k\u00fc veya E vitamini gibi \u00fcr\u00fcnler ile kombinasyonu \u00f6nerilir.<\/div>\n
    Glabridin:<\/u> Meyan k\u00f6k\u00fcn\u00fcn\u00fcn bile\u015fenidir ve tirozinaz aktivitesini inhibe edebilir.<\/div>\n
    Soya: <\/u>Melanozom transfer yola\u011f\u0131nda inhibisyon yapar.<\/div>\n
    Arbutin\/deoxyArbutin:<\/u> Arbutin deride hidrokinon d\u00f6n\u00fc\u015f\u00fcr. Doza ba\u011f\u0131ml\u0131 tirozinaz enzimi inhibisyonu yapar.<\/div>\n
    Niasinamid: <\/u>Melanositlerden keratinositlere melanozom transferini azalt\u0131r \u00e7o\u011fu ayd\u0131nlat\u0131c\u0131 \u00fcr\u00fcn i\u00e7inde mevcut<\/div>\n
    N-Asetilglukozamin (NAG)<\/u>: Bir karbonhidratt\u0131r ve tirozinaz enzimin olu\u015fumunu inhibe ederek melanin sentezini azalt\u0131r.<\/div>\n
    Glikolik Asit:<\/u> Do\u011frudan tirozinaz enzimini inhibe eder.<\/div>\n
    Lignin Peroxidaz:<\/u> Deride melaninin par\u00e7alanmas\u0131 ve enzimatik oksidasyonunu hedefleyerek renk a\u00e7an yeni bir tedavidir.<\/div>\n
    Traneksamik Asit:<\/u> Melanin sentezinin bir\u00e7ok yola\u011f\u0131nda inhibisyon yaparak hem a\u011f\u0131zdan, hem enjeksiyon hem de topikal krem olarak uygulanabilen bir molek\u00fcld\u00fcr.<\/div>\n
    Genellikle bu molek\u00fcllerin kar\u0131\u015f\u0131m \u015feklinde kombinasyonlar\u0131 ile daha ba\u015far\u0131l\u0131 sonu\u00e7lar elde edilmektedir ve en s\u0131k kullan\u0131lan \u00fcr\u00fcn hidrokinondur.<\/div>\n
    Piramidin sonraki basama\u011f\u0131nda, plateletten zengin plazma, uygun i\u00e7erikli mezoterapi uygulamalar\u0131 gibi enjeksiyonlu uygulamalar, kimyasal peelingler ve enerji bazl\u0131 tedaviler yani lazerler bulunmaktad\u0131r.<\/div>\n
    Lazer tedavileri hem pigmentasyon hem de damarsal kaynakl\u0131 nedenlerde olduk\u00e7a ba\u015far\u0131l\u0131 sonu\u00e7lar vermektedir. Lazerler dalga boyu ve tiplerine g\u00f6re temel olarak; melaninin par\u00e7alanmas\u0131, yeni kollajen \u00fcretimini uyarmak ve var olan yap\u0131n\u0131n yeniden \u015fekillenmesini sa\u011flayarak, bu b\u00f6lge derisinin kalitesini ve parlakl\u0131\u011f\u0131n\u0131 artt\u0131r\u0131r.<\/div>\n
    Bu ama\u00e7la BroadBand Lazerler, Alt\u0131n \u0130\u011fne Radyofrekans Lazerler, Thulium Lazerler ve Leke tedavisinde hala en \u00e7ok kullan\u0131lan ve lazerler aras\u0131nda ilk basamakta \u00f6nerilen QS ND: YAG Lazerler kullan\u0131lmaktad\u0131r.<\/div>\n
    Leke tedavi piramidinin en son basama\u011f\u0131nda; traneksamik asit hap tedavisi bulunmaktad\u0131r. Bilimsel veriler ve sonu\u00e7lara dayal\u0131 olarak, olduk\u00e7a ba\u015far\u0131l\u0131 olan bu tedavinin en b\u00fcy\u00fck handikap\u0131 etiket d\u0131\u015f\u0131 kullanmam\u0131z yani leke tedavisinde hen\u00fcz FDA onayl\u0131 olmamas\u0131d\u0131r. Bu nedenle, olduk\u00e7a se\u00e7ili vakalarda onam al\u0131narak verilmektedir.<\/div>\n
    B\u00fct\u00fcn bu tedavilere ek olarak, botulinum toksini uygulamas\u0131n\u0131n melanositler, keratinositler ve fibroblastlar\u0131n etkile\u015fimine arac\u0131l\u0131k eden proinflamatuar sitokinleri inhibe ederek melanogenez yolunu yani, lekeyi olu\u015fturan melanin \u00fcretimini engelledi\u011fi g\u00f6sterilmi\u015ftir. Bu nedenle leke protokol\u00fcne ekleyebiliyoruz<\/div>\n
    Bitkisel takviyeler (polypodium leucotomos, karotenoidler ve melatonin) de leke tedavisinde ba\u015far\u0131y\u0131 art\u0131rmak i\u00e7in eklenebilmektedir. \u00d6zellikle uyku uyan\u0131kl\u0131k d\u00f6ng\u00fcs\u00fc veya uyku kalitesi bozuk hastalarda ben de melatonin \u00f6nerisinde bulunuyorum.<\/div>\n
    LEKE TEDAV\u0130S\u0130 PLANLAMASI NASIL OLMALI?<\/strong><\/div>\n
    Leke tedavisinde planlama ve tedavi se\u00e7imi; bireyin deri yap\u0131s\u0131, ya\u015f\u0131, hastal\u0131klar\u0131, kulland\u0131\u011f\u0131 ila\u00e7lar ve deri tipine g\u00f6re de\u011fi\u015fkenlik g\u00f6sterir.<\/div>\n
    \u00d6ncelikle leke tablosu olan bir hastaya yakla\u015f\u0131mda, leke tedavisinin uzun soluklu ve sab\u0131r gerektiren bir durum oldu\u011fu, lekenin tamamen ge\u00e7meyece\u011fi ve her yaz mevsiminde tekrarlama e\u011filimi olabilece\u011fi ifade edilmelidir.<\/div>\n
    Leke problemi tedavi edilirken yap\u0131lan uygulamalarla:<\/div>\n
    -Deri kalitesi artaca\u011f\u0131 i\u00e7in lekenin daha az g\u00f6r\u00fcn\u00fcr olmas\u0131,<\/div>\n
    -Daha az \u015fiddette tekrar etmesi sa\u011flan\u0131r.<\/div>\n
    Tabi ki g\u00fcne\u015ften korunma davran\u0131\u015flar\u0131n\u0131n d\u00fczenli ve do\u011fru olmas\u0131 ve altta yatan organik bir neden varsa tedavisinin sa\u011flanmas\u0131 ve s\u00fcrd\u00fcr\u00fclmesi durumunda\u2026<\/div>\n","protected":false},"excerpt":{"rendered":"

    LEKE (H\u0130PERP\u0130GMENTASYON) VE DER\u0130 Kar\u015f\u0131l\u0131kl\u0131 ileti\u015fimde en \u00e7ok dikkat etti\u011fimiz b\u00f6lge, y\u00fcz b\u00f6lgesidir. Bu b\u00f6lgede bulunan ve \u00e7o\u011fu bireyin ya\u015fam kalitesini bozan sorunlardan biri olan leke, dermatolojik hastal\u0131klar aras\u0131nda en \u00e7ok zorland\u0131\u011f\u0131m\u0131z deri problemlerinden biridir. \u00d6zellikle kad\u0131nlarda, estetik a\u00e7\u0131dan daha b\u00fcy\u00fck endi\u015feler do\u011furdu\u011funu da ekleyelim. DER\u0130 RENG\u0130 FARKLILIKLARI VE F\u0130ZYOLOJ\u0130S\u0130NE DA\u0130R Derimiz renk a\u00e7\u0131s\u0131ndan farkl\u0131 […]<\/p>\n","protected":false},"author":1,"featured_media":297,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-296","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dermatolojik-tedaviler"],"yoast_head":"\nLeke Tedavisi Fiyatlar\u0131 Ankara 2024 - Uzm.Dr. Fatma Erden<\/title>\n<meta name=\"description\" content=\"Leke tedavisi ile cildinizdeki lekeleri azalt\u0131n. 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